New ADIPOA-2 publication from Istituto Ortopedico Rizzoli di Bologna

Congratulations to the ADIPOA-2 team at the Istituto Ortopedico Rizzoli di Bologna for their latest publication in the Journal of Orthopaedic Research: “Osteoarthritic milieu affects adipose-derived mesenchymal stromal cells”. The research was conducted by the team of C Manferdini, F Paolella, E Gabusi, L Cattini, M Rojewski, H Schrezenmeier, O Addimanda, R Meliconi, G Lisignoli.

DOI: 10.1002/jor.24446.

Read the entire list of ADIPOA-2 acknowledged publications here.

IOR researchers present ADIPOA-2 at Stem Cell Research Italy meeting; Dr Manferdini takes first prize


Pictured above: Drs Gina Lisignoli and Cristina Manferdini, IOR

ADIPOA-2 researchers at the Rizzoli Orthopaedic Institute in Bologna, Dr Gina Lisignoli and Dr Cristina Manferdini of the Laboratory di Immuno-rheumatology and Tissue Regeneration have presented two ADIPOA-2 studies at the 10th Stem Cell Research Italy meeting. Hosted in Napoli, the meeting took place on June 5-7, 2019.

Dr Manfredini was awarded the first prize for the best poster presentation. Congratulations, Cristina!

Read the article in Italian in the IOR Rizzoli July 2019 newsletter on page 2 here.

International Clinical Trials Day 2019, Galway

The HRB Clinical Research Facility Galway in Ireland hosted a public event to celebrate International Clinical Trials Day on May 20th 2019. Exhibition stands were on display and informational meetings were held throughout the day to inform the public of all areas of clinical research being undertaken at the facility.

A particular stand was dedicated to the CRF Galway’s stem cell work to inform the public of the cell therapy projects the CRF Galway are undertaking with partners within the National University of Ireland Galway and with European partners.  ADIPOA-2 was showcased here, as were related projects VISICORT and NEPHSTROM.

Dr Veronica McInerney comments, “Great interest was expressed in this evolving therapeutic area with approximately 100 members of the public stopping by to hear about what cell therapy involves and to learn about the projects from the clinical researchers on the day.”

Dr Mary Murphy, Dr Veronica McInerney CRF Galway


Clinical researchers, CRF Galway

Radboud University Medical Centre publish ADIPOA-2 study

The study “IL-1β-mediated activation of adipose-derived mesenchymal stromal cells results in PMN reallocation and enhanced phagocytosis. A possible mechanism for the reduction of osteoarthritis pathology” by the team of Stephanie C.M. van Dalen, Arjen B. Blom, Birgitte Walgreen, Annet W. Slöetjes, Monique M.A. Helsen, Edwin J.W. Geven, Thomas Vogl, Johannes Roth, Fons A.J. van de Loo, Marije I. Koenders, Louis Casteilla, Peter M. van der Kraan, Martijn H.J. van den Bosch, Peter L.E.M. van Lent was recently published in Frontiers in Immunology.

Congratulations to our team at Radboud University Medical Centre Nijmegen pictured below!

DOI: 10.3389/fimmu.2019.01075

Download the pdf here.

Partners at CCMI, NUI Galway offer training workshops

Our partners at the Centre for Cell Manufacturing Ireland (CCMI) based at the National University of Ireland Galway have organized a workshop series:  “Selection, Validation and Implementation of Rapid Microbiological Methods for ATMPs“. This event will take place in Galway, Ireland on the 12th and 13th of June 2019.

For more information, download the flyer here.

ADIPOA-2 work featured in Italian health magazine “Viversani”

The work of the ADIPOA-2 teams at the Universita Degli Studi di Padova and the Rizzoli Orthopaedic Institute has recently been featured in the popular press health magazine “Viversani” or “To Life with Health”. On pages 46-47, find the article Dal “grasso” un aiuto contro l’osteoartrosi  where Prof Riccardo Meliconi of the Reumatologia all’Instituto Ortopedico Rizzoli di Bologna and Prof Roberta Ramonda of the Rheumatology Unit University of Padova-Italy have consulted with the reporter Chiara Di Paola to feature the research.

Rizzoli Orthopaedic Institute researchers present ADIPOA-2 widely

Researchers at the Rizzoli Orthopaedic Institute in Bologna have been busy presenting ADIPOA-2 findings at a variety of national and international conferences. Below please find a list of their dissemination activities to inform and educate others in the research community of our scientific plan and findings.

  1. Oral presentation at “Le Cellule Staminali nella Medicina”. Round table forum: LE CELLULE STAMINALI NELLA MEDICINA TRASLAZIONALE “: Cellule Staminali e Osteoartrite: Il Progetto ADIPOA-2; Gina Lisignoli and Riccardo Meliconi
  2. Oral presentation at the ICRS 2018, 13-14 December 2018 Milan, Italy. Title: ADIPOA Project: Adipose-Derived Stem Cells Biological Effects; Gina Lisignoli.
  3. Oral presentation at the AICC (31st annual conference of Italian Association of Cell Culture), 27-28 November 2018 Bologna, Italy. Title: Mesenchymal stem cells and synoviocytes:development of an in vitro co-culture model; Gina Lisignoli.
  4. Oral presentation at the EORS 2018, 25- 28 September 2018, Galway, Ireland. Title: Adipose mesenchymal stromal cells characteristics are differently modulated by osteoarthritic milieu. Cristina Manferdini, Francesca Paolella, Elena Gabusi, Luca Cattini, Hubert Schrezenmeier, Gina Lisignoli.
  5. Oral presentation at the EORS 2018, 25- 28 September 2018, Galway, Ireland. Title: Switching of the pro-inflammatory profile of synovial osteoarthritic macrophages by adipose mesenchymal stromal cells; Cristina Manferdini, Francesca Paolella, Elena Gabusi, Laura Gambari,  Sandrine Fleury-Cappellesso, Andrea Barbero,  Mary Murphy, Gina Lisignoli.
  6. Oral presentation at OARSI 2018,  26 -29 April 2018, Liverpool, UK. Title: Adipose mesenchymal stromal cells determine the switching of the pro-inflammatory profile of synovial osteoarthritic macrophages; Cristina Manferdini, Francesca Paolella, Elena Gabusi, Laura Gambari,  Giuseppe Filardo, Sandrine Fleury-Cappellesso, Andrea Barbero,  Mary Murphy, Gina Lisignoli.
  7. Poster presentation at the SCR meeting 25-27 May 2017, Chieti, Italy. Title: Switching of a M1 inflammatory macrophages subset by adipose stromal cells contributes to resolution of osteoarthritic synovial tissue inflammation; C Manferdini, F Paolella, E Gabusi, L Gambari, L Cattini, A Piacentini, S Fleury-Cappellesso, A Barbero, M Murphy, G Lisignoli.
  8. Poster presentation at the EULAR 2017 14-17 June 2017 Madrid, Spain. Title: Adipose stromal cells exert specific effects on osteoarthritic synovial macrophages; Manferdini C, Paolella F., Gabusi E., Piacentini A., Gambari L., Cattini L., Fleury-Cappellesso S., Lisignoli G
  9. Oral presentation at the ICRS held 24-27 September 2016, Sorrento, IT. Title: Adipose stromal cells exert specific effects on osteoarthritic synovial macrophages; Manferdini C, Paolella F., Gabusi E., Piacentini A., Gambari L., Cattini L., Fleury-Cappellesso S.,  Lisignoli G.
  10. Poster presentation at TERMIS 27 June-04 July 2016, Uppsala, Sweden Title: Adipose stromal cells effects on osteoarthritic synovial cells are dependent by macrophages; C Manferdini, F Paolella, E Gabusi, L Gambari, L Cattini, S Fleury-Cappellesso, A Barbero, G Lisignoli.
  11. Poster presentation at the OARSI 2016 World Congress, March 31-April 3 Amsterdam, Netherlands. Title: Adipose stromal cells effects on osteoarthritic synoviocytes are dependent by macrophages; Manferdini C,  Gabusi E., Piacentini A.,  Paolella F., Fleury-Cappellesso S., Jorgensen C., Noël D., Barbero A., Lisignoli G.
  12. Poster presentation at the SCR meeting 21– 23 June 2016 Bologna, Italy. Title: Adipose stromal cells effects on osteoarthritic synovial cells are dependent by macrophages; C Manferdini1, F Paolella1, E Gabusi1, L Gambari, L Cattini, S Fleury-Cappellesso, A Barbero4, G Lisignoli

Frank Barry gives keynote presentation at Zoobiquity Colorado meeting

On October 5 and 6, 2018, Zoobiquity Colorado: Connecting Human and Animal Health through Regenerative Medicine will take place. Here, ADIPOA-2 Coordinator Prof Frank Barry of the Regenerative Medicine Institute at the National University of Ireland Galway will deliver a keynote presentation, ‘Cell Strategies for Arthritic Disease’.

Zoobiquity Colorado aims to uncover the astonishing connection between human and animal health by highlighting laboratory and clinical research of human and veterinary investigators and fostering future collaboration across disciplines.

Prof Frank Barry takes ADIPOA-2 on the road

ADIPOA-2 Coordinator Professor Frank Barry of NUI Galway has had a busy 2018 thus far. He has organised and been invited to present at several conferences, provide keynote talks and lead seminars around the world raising the profile of ADIPOA-2 internationally within academic and industrial circles.

Here is a list of events:

  1. Speaker on August 17 2018: Georgia Tech CMaT Annual Retreat, Madison WI, USA
  2. Invited Seminar on July 23 2018: Colorado State University Veterinary Orthopaedic Centre Fort Collins, CO, USA
  3. Keynote Speaker on July 6 2018: Whitaker Bioengineering Symposium, Galway, Ireland
  4.  Keynote Speaker; Conference and workshop organiser on June 28 2018: CALIN Cell and Gene Therapy Industry Symposium, Galway, Ireland
  5.  Invited Seminar on June 7 2018: University of Guelph School of Veterinary Medicine, Guelph, ON, Canada
  6.  Keynote Speaker on May 24 2018: Canadian Connective Tissue Conference, Toronto, ON, Canada
  7. Plenary Speaker on May 18 2018: American Society for Gene and Cell Therapy Annual Conference, Chicago, IL, USA
  8.  Keynote Speaker on May 12 2018: Canadian Bone and Joint Conference, London ON, Canada
  9. Plenary Speaker on May 2 2018: International Society for Cellular Therapy Annual Conference, Montreal, QC, Canada
  10.  Seminar Speaker in January 2018: Division of Orthopaedics, University of Toronto, ON, Canada

Here is some digital press coverage from the roadshow:

 

ADIPOA-2 features in Azienza Opedaliera di Padova June newsletter 2018

On pages 8-12 of the June 2018 Informasanità, the Azienda Ospedaliera di Padova newsletter, ADIPOA-2 is featured. The role within the project and the team at the Rheumatology Unit, Department of Medicine – DIMED, University of Padova (UNIPD) are highlighted.

Read the entire publication here:  INFORMASANITA-GIUGNO-2018

Read more about the Rheumatology Unit of the Department of Medicine (DIMED) of University of Padova here.