ADIPOA2 meets the public at the Galway Science & Technology Festival 2017

ADIPOA-2 researchers at NUI Galway exhibited at the Galway Science and Technology Forum on 26 November 2017. In excess of 20,000 people attended the exhibition day. The NUI Galway regenerative medicine stand was the brainchild of Dr Siobhán Gaughan who works across several EU-funded stem cell projects coordinated at NUI Galway. Researchers Georgina Shaw, Amy Burke and Eka Mukeria, along with Siobhán Gaughan were on hand to explain the cell research ongoing at the university, the objectives and mission of ADIPOA-2, and to inspire the next generation of stem cell scientists. Several activities were on exhibition.

Microscopes were on hand to display bone marrow-derived MSCs and cells differentiated into fat cells. This display was used as an aid to discuss or explain how we need stem cells in our body to replace dead cells in our body and how these stem cells can differentiate down different pathways to make new fat, bone, skin and muscle.

Anatomical models were exhibited to explain the importance of the three EU-funded clinical trials involving stem cells that currently taking place through the Regenerative Medicine Institute (REMEDI) at NUI Galway:

  • ADIPOA-2 is treating osteoarthritis using adipose-derived stromal cells.  Cells are isolated from fat tissue procured by liposuction, expanded under GMP (good manufacturing practices) conditions in Centre for Cell Manufacturing in Ireland (CCMI), the cell manufacturing facility at NUI Galway and injected into the knee of people with osteoarthritis.  The treatment aims to reduce the pain and inflammation.
  • VISICORT project aims to treat corneal transplant rejection by using an infusion of human bone marrow-derived stromal cells obtained from healthy bone marrow donors.  The cells are expanded in CCMI cell manufacturing facility as a cell product, frozen and shipped to Charite Hospital in Berlin where corneal transplant patients will be treated.  The cell therapy used in this trial aims to reduce the risk of rejection of the corneal transplant.
  • NEPHSTROM is a project involving a clinical trial which aims to treat diabetic kidney disease using bone marrow-derived stem cells. Complications of diabetes were explained to help contextualise this project and a diabetic foot model with a black toe was also on hand.

AUTOSTEM is an EU-funded project to develop a robotic clean room platform system for the manufacture of large quantities of cells in bioreactors.  These large quantities of therapeutic cells will be required once cell therapy clinical trial results prove successful and a cohort of patients will be line up for treatment worldwide. The AUTOSTEM video ran on a loop for display to the public.

Special thanks to Dr Paul Lohan for tech support with the films and Dr Georgina Shaw for supplying the cells for display. Also to Ning Ge and Yicheng Ding of the iPS cell group at REMEDI led by Prof Sanbing Shen.

For more photos and information about the Galway Science & Technology Festival 2017, please follow us on Twitter @Adipoa2

For more information on the projects mentioned, please see:

  • ADIPOA-2 http://adipoa2.eu/ is led by Prof Frank Barry. Cartilage repair in the knee using stem cells derived from fat.
  • VISICORThttp://visicort.eu/ is coordinated by Prof Matthew Griffin. Infusions of bone marrow (BM)- derived stem cells to treat people with corneal transplants avoid transplant rejection.
  • NEPHSTROM http://nephstrom.eu/ Led by Prof Tim O’Brien. Infusions of BM-MSCs to treat patients with chronic kidney disease
  • AUTOSTEM http://www.autostem2020.eu/ is coordinated by Prof Mary Murphy. This project is developing a robotic platform and bioreactor which will grow the many cells required to treat future patients. A model bioreactor was available for demonstration.

Galway Advertiser Science Week 2017

ADIPOA2 is presented at the START competition in May 2017, Galway

Does it help your fitness to have an event as a goal when you are training? Can cartoons and comics help children to achieve better results in tests? How would you even find out?

Dr Siobhán Gaughan, NUI Galway Programmme Manager of ADIPOA-2, VISICORT and AUTOSTEM was on hand at the awards ceremony for a schools’ competition called “START” whose aim was to encourage school students to come up with interesting questions and to design and run trials to answer them in a scientific way.

“It is one of the only initiatives out there that is teaching children about randomised trials,” says Dr Sandra Galvin, who co-ordinates the Health Research Board Trials Methodology Research Network, which runs the START initiative. “We need more people to participate in trials to improve healthcare, so there is that big important picture here, and it comes down to kids having fun and they take the message home.” For more information about taking part, see hrb-tmrn.ie/start-competition.

Siobhán created and managed a presentation area for the three projects, spoke to the school groups and visitors who were interested in the planned clinical trials for ADIPOA-2 and VISICORT taking place at NUI Galway’s Clinical Research Facility. A sister project, AUTOSTEM was also represented. This project is looking ahead of the clinical trials in order to meet the needs of the clinics in the future by developing automated cell factories to produce the vast quantities of cells which will be required should the clinical trials prove successful.

ADIPOA2 Trial commences in Germany

ADIPOA2 partners Evangelisches Waldkrankenhaus Spandau today announced the enrollment of the first patients in the German arm of the ADIPOA2 trial.

ADIPOA2 announces the start of Italian trial

The ADIPOA2 has successfully secured regulatory approval for the Italian part of its clinical trial. Click here and here to see some of the coverage of this exciting news in the Italian media.

 

ADIPOA2 Trial Commences in Italy

ADIPOA2’s Italian partners, Instituto Ortopedico Rizzoli de Bologna, announce the launch of the Italian arm of the ADIPOA2 trial.

Click here for a copy of IOR’s press release.

ADIPOA2 researchers highlight the project at ICRS World Congress

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ADIPOA2 researchers Prof. Frank Barry and Dr Mary Murphy (NUIG) attended the 13th World Congress of the International Cartilage Repair Society in Sorrento, Italy, on 24th – 27th September. The work of the ADIPOA2 project was highlighted during the conference sessions.

ADIPOA2 discussed at A FACTT meeting

screen-shot-2016-10-06-at-19-33-02 ADIPOA2 was one of a number of projects discussed at the A FACTT meeting in Galway this week. A FACTT is an Action to Focus and Accelerate Cell-based Tolerance-Inducing Therapies, funded through the COST (European Cooperation in Science and Technology) Programme. The meeting is being hosted by NUIG and runs from 5-7 October.

ADIPOA2 at the CRFG Open House

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ADIPOA2 plenary in Bologna

The ADIPOA2 team met in Bologna on June 20-21, hosted by the Istituto Ortopedico Rizzoli. The team shared updates on all aspects of the project, including regulatory engagement, planning for the clinical trial, research on the mechanism of action of ASCs, and the dissemination and exploitation of the project’s results.

The picture below shows the ADIPOA2 team outside the IOR.

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STEM CELL REVOLUTIONS documentary screening, NUI Galway

Featuring beautiful hand-drawn animations and interviews with leading stem cell scientists, STEM CELL REVOLUTIONS charts the history and scientific evolution of stem cell research – from the earliest experiments that first revealed stem cells in the body, to leading current scientific and clinical developments. Watch the trailer here

Question & answer session to follow led by Profs Tim O’ Brien and Matt Griffin

WHEN
WHERE
Clinical Science Institute (CSI) Lecture Theatre – Costelloe Road NUI Galway, H91 YR71 Galway – View Map

For more details and to book tickets click here.