ADIPOA2 Trial Commences in Italy

ADIPOA2’s Italian partners, Instituto Ortopedico Rizzoli de Bologna, announce the launch of the Italian arm of the ADIPOA2 trial.

Click here for a copy of IOR’s press release.

ADIPOA2 researchers highlight the project at ICRS World Congress


ADIPOA2 researchers Prof. Frank Barry and Dr Mary Murphy (NUIG) attended the 13th World Congress of the International Cartilage Repair Society in Sorrento, Italy, on 24th – 27th September. The work of the ADIPOA2 project was highlighted during the conference sessions.

ADIPOA2 discussed at A FACTT meeting

screen-shot-2016-10-06-at-19-33-02 ADIPOA2 was one of a number of projects discussed at the A FACTT meeting in Galway this week. A FACTT is an Action to Focus and Accelerate Cell-based Tolerance-Inducing Therapies, funded through the COST (European Cooperation in Science and Technology) Programme. The meeting is being hosted by NUIG and runs from 5-7 October.

ADIPOA2 at the CRFG Open House


ADIPOA2 plenary in Bologna

The ADIPOA2 team met in Bologna on June 20-21, hosted by the Istituto Ortopedico Rizzoli. The team shared updates on all aspects of the project, including regulatory engagement, planning for the clinical trial, research on the mechanism of action of ASCs, and the dissemination and exploitation of the project’s results.

The picture below shows the ADIPOA2 team outside the IOR.

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STEM CELL REVOLUTIONS documentary screening, NUI Galway

Featuring beautiful hand-drawn animations and interviews with leading stem cell scientists, STEM CELL REVOLUTIONS charts the history and scientific evolution of stem cell research – from the earliest experiments that first revealed stem cells in the body, to leading current scientific and clinical developments. Watch the trailer here

Question & answer session to follow led by Profs Tim O’ Brien and Matt Griffin

Clinical Science Institute (CSI) Lecture Theatre – Costelloe Road NUI Galway, H91 YR71 Galway – View Map

For more details and to book tickets click here.

Report on EU MSC2 2015 meeting – Shaping the future of MSC Therapy

ADIPOA-2 researchers participated in the EU-MSC2 meeting in Leiden on the 7th and 8th of September 2015

The two-day meeting brought together researchers from nine EU-funded projects pursuing MSC research. In addition to REDDSTAR, other projects represented at the meeting included REDDSTARStellar, RETHRIM, REACH, VISICORT, MERLIN,SCIENCE and NEPHSTROM. After a welcome from Henri Lenferink, Mayor of Leiden, European Commission Project Officer Dr. Charles Kessler highlighted the EU’s continued support to regenerative medicine research, and a Fundamental MSC Biology lecture was delivered by Prof. Dr. Yufang Shi from the Institute of Health Sciences, Shanghai, China. Following on, the nine EU-funded projects were presented.

On the second day of the meeting, interactive panel discussions about key challenges faced when developing MSC therapies, including scientific obstacles, regulatory and ethical issues, technological hurdles and commercialisation barriers ensued. Opportunities for future collaborations and the harmonisation of MSC research in Europe were discussed.

A report of the EU MSC2 meeting is available here.

Winning essay writers visit REMEDI

The Regenerative Medicine Institute (REMEDI) at NUI Galway was delighted to host a visit by winning essay writers from St Nathy’s College,  Ballaghdereen, Co. Roscommon. Each of the winning students had written an essay on the topic of stem cell, outlining the history of their discovery, and their potential to revolutionise the treatment of a range of medical conditions. The winning students – Michael Raleigh (1st), Tom Murray (2nd), Mohammad Hamid (3rd), and Annie Quinlan (3rd) – and John Guilfoyle, their teacher, were treated to a tour of REMEDI’s facilities, and met with members of the ADIPOA-2 team. The competition was initiated by Oonagh Redmond, a teacher at St Nathy’s, and was organised by members of the ADIPOA-2 team. Prizes were sponsored by ADIPOA-2, VISICORT, and REDDSTAR.

Prof. Frank Barry, coordinator ADIPOA-2, pictured with the winning students and their teacher.

Prof. Frank Barry, coordinator ADIPOA-2, pictured with the winning students and their teacher.



The Sunday Express covers ADIPOA-2

A recent front page article in the Sunday Express reports on the ADIPOA-2 project.

Sports Surgery Clinic Plays Leading Role in European Clinical Trial on Stem Cell Therapy for Osteoarthritis of the Knee

Prevention of progression of Osteoarthritis will improve the lives of millions of sufferers

Tuesday, 12th May 2015: The Sports Surgery Clinic in Santry has today announced it’s participation in the ADIPOA-2 stem cell trial for Osteoarthritis (OA), the aim of which is to find treatment(s) for the disease and prevent it’s progression.

This large-scale clinical trial using adult stem cells to treat knee osteoarthritis is expected to be underway across Europe by the end of 2015. Almost €6 million has been granted to the project ‘ADIPOA-2’ by the EU’s Horizon 2020 research funding programme.

Osteoarthritis (OA) is an incurable and degenerative disease of the joints. Osteoarthritis has been identified as the eleventh highest contributor to disability and affects over 70 million people throughout Europe. There is currently no treatment to prevent progression of the disease.

ADIPOA-2 is contributing to the development of a novel cellular therapy for the treatment of osteoarthritis. The Sports Surgery Clinic’s participation in the programme is being led by Professor Cathal Moran, Consultant Orthopaedic Surgeon and Professor and Chair of Orthopaedics and Sports Medicine at Sports Surgery Clinic and Trinity College Dublin.

Sports Surgery Clinic is one of Ireland’s leading providers of clinical care in orthopaedics and sports medicine. Professor Cathal Moran has extensive international clinical and academic experience in orthobiological therapies as an orthopaedic surgeon specialising in Knee and Shoulder surgery and shall act as the Lead Knee Surgeon at SSC for ADIPOA-2. Under Professor Cathal Moran’s direction, Sports Surgery Clinic will facilitate the recruitment and treatment or trial participants as part of the multicentre international trial.

The overall scientific programme is being led by Professor Frank Barry, Scientific Director of the Regenerative Medicine Institute (REMEDI) at the National University of Ireland Galway. ADIPOA is a multi-phase programme of research in exploring new treatments for Osteoarthritis. In its first phase, the EU consortium ADIPOA1 carried out a first-in-man Phase I safety study in 18 patients. This study demonstrated that a single dose of stem cells cultured from the patients’ own fatty tissue (autologous adipose-derived mesenchymal stromal cells (ASCs)) injected into the knee was well tolerated, had no adverse effects, and resulted in an improvement in pain score and functional outcome. The results of this were sufficiently encouraging to warrant a larger, multi-centre Phase 2b trial to further test the safety and efficacy of autologous (patient derived) ACSs in the treatment of advanced OA of the knee. ADIPOA-2 will now build on the work of ADIPOA1 to deliver a randomised clinical trial across 10 hospitals in Europe involving 150 patients.

Speaking about the research Professor Cathal Moran said, “We are delighted at Sports Surgery Clinic to be participating in this landmark international clinical trial. Finding new ways to help delay the deterioration of joints caused by Osteoarthritis will improve the lives of millions of people worldwide, relieving them from debilitating pain, and helping them to continue an active life. Large scale stem cell research is in itself incredibly exciting and we look forward to contributing in the next phase of the programme. The specialised environment of Sports Surgery Clinic is an ideal environment in which to deliver highly regulated and controlled clinical trials”.

The international ADIPOA-2 clinical team includes clinicians from ten centres across Europe, including France, Germany, Italy, The Netherlands and two in Ireland – Sports Surgery Clinic in Dublin, and REMEDI in Galway. The first meetings of the ADIPOA-2 team took place in December last year in Paris, followed up by plenary planning meetings in Dublin in January 2015. The clinical trial will be delivered in conjunction with the National Clinical Research Facilities in Galway and Dublin. Clinical trial arrangements are being put in place at the partner institutes across Europe and Ireland and patient recruitment is anticipated in the first quarter of 2016.

Anyone interested in the programme; patients, doctors and other healthcare providers, are welcome to contact Professor Cathal Moran or Sports Surgery Clinic for more information. See and

For more information please contact:

Mary Gleeson | 086 2213077 |

About Professor Cathal Moran:

Professor Cathal Moran is the Professor and Chair of Orthopaedics and Sports Medicine at Trinity College Dublin and Consultant Orthopaedic Surgeon at Sports Surgery Clinic, Santry. He has also recently been appointed Honorary Professor at Royal College of Surgeons in Ireland and a Professorial Fellow of Trinity.

The new Academic Orthopaedic Unit at Trinity is only the second such academic unit in Ireland. In addition to it’s base in Orthopaedic Surgery, this is also the first ever Chair of Sports Medicine at an Irish University. The venture between Sports Surgery Clinic and Trinity College Dublin also represents the first time the clinical component of a Chair in a surgical discipline is hosted by a private hospital.

The Academic Unit of Orthopaedics and Sports Medicine in Trinity College Dublin’s School of Medicine will be be officially opened with the Inaugural Lecture of Cathal Moran, Professor of Orthopaedics and Sports Medicine in Trinity on May 13th at 18.00pm in the Trinity Biomedical Sciences Institute.

Professor Moran’s sub-specialty clinical interest is in the management of soft tissue and sports injuries, including ACL and ligament reconstruction, cartilage injury, meniscus repair and replacement, limb alignment surgery, rotator cuff and shoulder stabilisation surgery. He also performs shoulder and knee replacement surgery.

The new Academic Unit of Orthopaedics and Sports Medicine led by Professor Moran is based in the School of Medicine at Trinity College Dublin. The clinical host for the Chair is Sports Surgery Clinic and the unit functions in collaboration with Trinity Biomedical Sciences Institute, Trinity Centre for Bioengineering, and affiliated clinical sites.

In terms of research activity Professor Moran is a Principal Investigator at Trinity Centre for Bioengineering, RCSI Bioengineering and AMBER research centres. He links research at these centres to the development new options for treatment in Orthopaedics and Sports Medicine at Sports Surgery Clinic. His specific interest is in cartilage and soft tissue repair and regeneration, including the delivery of clinical trials in stem cell and biological treatment options for musculoskeletal injury and disease. Sports Surgery Clinic is host to many of these new trials.

Professor Moran completed his early training in Ireland, followed by sub-specialty training at the Orthopaedic Sports Medicine and Shoulder Fellowship at Hospital for Special Surgery and Cornell Medical College in New York, the Cartilage Repair Centre at Harvard Medical School and Brigham and Women’s Hospital in Boston, and Antwerp Orthopaedic Centre in Belgium.  He has also completed research periods at the Regenerative Medicine Institute (REMEDI) in Ireland; University of California, San Francisco; UC Irvine, California and Mayo Clinic in Rochester, Minnesota. He has worked extensively with professional athletes and teams across Ireland, the US and Europe, and has published over 50 papers and given over 200 presentations internationally.