Etablissement Francais du Sang
EFS is the French national blood service and is the main body involved in cellular therapy and development of ATMPs in France. Currently, EFS ensures the production of MSCs as ATMPS in France through coordination of national production platform of ECELL France program. With CNRS and INSERM, EFS in Toulosue has developed specific culture process for ex vivo expansion of ASCs (Adipose derived MSCs). EFS has developed a process for the selection and amplification of MSCs from adipose tissue and has specific programmes researching the definition and role of native MSCs in vivo, the differentiation through pathways involved in skeletal tissues repair (bone, cartilage and tendon) and the analysis and comprehension of genetic stability of cultured MSCs.
Luc Sensebé, MD, PhD heads Team 2 of the research unit STROMALab UMR5273 CNRS/EFS/UPS – INSERM U1031, and is the Medical and Scientific director in charge of adult stem cell at the EFS. He leads the MSC committee of International Society for Cellular Therapy (ISCT), and was coordinator of two F7P European Consortiums (CASCADE and REBORNE). His main research areas include sub-populations and role of native mesenchymal stem/stromal cells within bone marrow and adipose tissue and mesenchymal stem/stromal cells engineering for clinical applications in hematopoietic stem cell transplantation and regenerative medicine.