Our partners at Radboud University Medical Centre Nijmegen (Radboudumc) wrote a two-year project proposal called “Breaking the circle: Interleukin-1β stimulation of adipose stem cells increases their therapeutic efficacy in posttraumatic osteoarthritis via potentiation of anti-inflammatory actions in neutrophils”. This study is now funded by the Dutch Arthritis Association. Congratulations to the whole team!
The research team at Radboudumc who will work on this project consists of Wessel Theeuwes, Martijn van den Bosch, Arjen Blom, Sjoukje Mulder, Rogier Thurlings and Peter van Lent. They will investigate in more detail the interaction between adipose stem cells and the inflammatory response with focus at IL-1 β. They will use the outcome of these experiments to set up a clinical trial in which they would like to administer adipose stem cells locally to patients with a joint lesion. 80% of patients within a joint lesion develop OA with 12-24 years despite surgical repair. Dr Peter van Lent states, “The idea to dampen the development of post-traumatic OA by intra-articular injection of stem cells evolved out of ADIPOA2. Through this new project, we will continue cooperating with various research groups within ADIPOA2.”