New research award to our partners at Radboudumc

Our partners at Radboud University Medical Centre Nijmegen (Radboudumc) wrote a two-year project proposal called “Breaking the circle: Interleukin-1β stimulation of adipose stem cells increases their therapeutic efficacy in posttraumatic osteoarthritis via potentiation of anti-inflammatory actions in neutrophils”. This study is now funded by the Dutch Arthritis Association. Congratulations to the whole team!

The research team at Radboudumc who will work on this project consists of Wessel Theeuwes, Martijn van den Bosch, Arjen Blom, Sjoukje Mulder, Rogier Thurlings and Peter van Lent. They will investigate in more detail the interaction between adipose stem cells and the inflammatory response with focus at IL-1 β. They will use the outcome of these experiments to set up a clinical trial in which they would like to administer adipose stem cells locally to patients with a joint lesion. 80% of patients within a joint lesion develop OA with 12-24 years despite surgical repair. Dr Peter van Lent states, “The idea to dampen the development of post-traumatic OA by intra-articular injection of stem cells evolved out of ADIPOA2. Through this new project, we will continue cooperating with various research groups within ADIPOA2.”

Dr Peter van Lent’s Rheumatology group members at Nijmegan

Prof Frank Barry, NUI Galway presents ADIPOA-2 across 8 international fora

Coordinator Prof Frank Barry has had a busy few months in 2019 sharing news and updates on the ADIPOA-2 project. Audiences include scientists, clinicians, biotech industrialists and patient organizations.

Read more

INSERM PI Dr Yves-Marie Pers presents ADIPOA-2 at U of Los Andes in Chile

Last week, Dr Yves-Marie Pers was an invited speaker at the University of Los Andes in Santiago, Chile. There, he delivered a talk entitled “Osteoarthritis and immunomodulation with stem cells” to a group of 40 researchers. ADIPOA-2 was acknowledged in the presentation.

ADIPOA-2 publication in Biomaterials journal

Congratulations to the team of  Maxime Ruiz, Karine Toupet, Marie Maumus, Pauline Rozier, Christian Jorgensen and Daniéle Noel for the publication of the paper “TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected by extracellular vesicles.” The open access paper published in Biomaterials 226 (2020) 119544 was made available online on 11 October 2019.

Read the paper here.

ADIPOA-2 presented by PI Yves-Marie Pers at ISCT 2019 in Mexico

Dr Yves-Marie Peres

ADIPOA-2 PI Yves-Marie Pers, M.D., PhD. of INSERM Montpellier gave an oral presentation at the International Society for Cell and Gene Therapy (ISCT) meeting in Mexico City on 23 October 2019. The title of his talk was “Mesenchymal stem cells: from bench to bedside” where ADIPOA-2 was presented and acknowledged. Approximately 200 people attended Yves’ talk. The ISCT South and Central America Regional Forum took place on October 21-23, 2019.

ISCT is a global society of clinicians, regulators, technologists, and industry partners with a shared vision to translate cellular therapy into safe and effective therapies to improve patients’ lives. ISCT Members gain access to an influential global community of peers, experts, and organizations invested in cell therapy. ISCT offers a unique collaboration between academia, regulatory bodies, and industry partners in cell therapy translation.

Pintail hosts ADIPOA-2 plenary meeting, 3 September 2019 in Dublin

The ADIPOA-2 consortium met for a plenary meeting on September 3, 2019, in Dublin.

ADIPOA-2 plenary meeting, September 3, 2019, Dublin

This was a critical meeting to assess progress, obstacles and achievements in the ADIPOA2 clinical trial.  Every partner in the clinical, manufacturing and scientific arenas was represented.  Some key points have emerged during this project summit meeting on which all the partners are in strong agreement:  there has been a great deal of progress in implementing the clinical trial at orthopaedic hospitals across Europe.  For all of these hospitals, this is an innovative and ground-breaking technology and requires a multidisciplinary and coordinated approach, which has been successfully achieved.  In addition, a multinational clinical trial such as this requires a comprehensive approach in terms of regulatory affairs in several European countries, as well as the implementation of harmonised protocols.  This has all been achieved and a great deal has been learned about regulatory strategies for cellular therapies in Europe.  On another level, complex manufacturing protocols have been put in place and validated in GMP facilities in France, Ireland and Germany. 

“We have been able to advance the progression of complex cell therapies across Europe and learned valuable lessons about clinical trial implementation, national and harmonised approaches to the regulation of manufacturing and clinical testing.  We have a consortium of partners from France, Germany, Italy, Ireland, Netherlands and UK that is strongly aligned and everyone shares the same vision and determination of delivering innovative therapies to patients.  We have opened up strong opportunities for commercialisation and we expect to see the fruits of this in the near future.   Because of the support projects such as this receive from Horizon programmes, there is every reason to predict that Europe will continue to be a global leader in cell therapy”. 

New ADIPOA-2 publication from Istituto Ortopedico Rizzoli di Bologna

Congratulations to the ADIPOA-2 team at the Istituto Ortopedico Rizzoli di Bologna for their latest publication in the Journal of Orthopaedic Research: “Osteoarthritic milieu affects adipose-derived mesenchymal stromal cells”. The research was conducted by the team of C Manferdini, F Paolella, E Gabusi, L Cattini, M Rojewski, H Schrezenmeier, O Addimanda, R Meliconi, G Lisignoli.

DOI: 10.1002/jor.24446.

Read the entire list of ADIPOA-2 acknowledged publications here.

IOR researchers present ADIPOA-2 at Stem Cell Research Italy meeting; Dr Manferdini takes first prize

Pictured above: Drs Gina Lisignoli and Cristina Manferdini, IOR

ADIPOA-2 researchers at the Rizzoli Orthopaedic Institute in Bologna, Dr Gina Lisignoli and Dr Cristina Manferdini of the Laboratory di Immuno-rheumatology and Tissue Regeneration have presented two ADIPOA-2 studies at the 10th Stem Cell Research Italy meeting. Hosted in Napoli, the meeting took place on June 5-7, 2019.

Dr Manfredini was awarded the first prize for the best poster presentation. Congratulations, Cristina!

Read the article in Italian in the IOR Rizzoli July 2019 newsletter on page 2 here.

International Clinical Trials Day 2019, Galway

The HRB Clinical Research Facility Galway in Ireland hosted a public event to celebrate International Clinical Trials Day on May 20th 2019. Exhibition stands were on display and informational meetings were held throughout the day to inform the public of all areas of clinical research being undertaken at the facility.

A particular stand was dedicated to the CRF Galway’s stem cell work to inform the public of the cell therapy projects the CRF Galway are undertaking with partners within the National University of Ireland Galway and with European partners.  ADIPOA-2 was showcased here, as were related projects VISICORT and NEPHSTROM.

Dr Veronica McInerney comments, “Great interest was expressed in this evolving therapeutic area with approximately 100 members of the public stopping by to hear about what cell therapy involves and to learn about the projects from the clinical researchers on the day.”

Dr Mary Murphy, Dr Veronica McInerney CRF Galway

Clinical researchers, CRF Galway

Radboud University Medical Centre publish ADIPOA-2 study

The study “IL-1β-mediated activation of adipose-derived mesenchymal stromal cells results in PMN reallocation and enhanced phagocytosis. A possible mechanism for the reduction of osteoarthritis pathology” by the team of Stephanie C.M. van Dalen, Arjen B. Blom, Birgitte Walgreen, Annet W. Slöetjes, Monique M.A. Helsen, Edwin J.W. Geven, Thomas Vogl, Johannes Roth, Fons A.J. van de Loo, Marije I. Koenders, Louis Casteilla, Peter M. van der Kraan, Martijn H.J. van den Bosch, Peter L.E.M. van Lent was recently published in Frontiers in Immunology.

Congratulations to our team at Radboud University Medical Centre Nijmegen pictured below!

DOI: 10.3389/fimmu.2019.01075

Download the pdf here.

ADIPOA-2 work featured in Italian health magazine “Viversani”

The work of the ADIPOA-2 teams at the Universita Degli Studi di Padova and the Rizzoli Orthopaedic Institute has recently been featured in the popular press health magazine “Viversani” or “To Life with Health”. On pages 46-47, find the article Dal “grasso” un aiuto contro l’osteoartrosi  where Prof Riccardo Meliconi of the Reumatologia all’Instituto Ortopedico Rizzoli di Bologna and Prof Roberta Ramonda of the Rheumatology Unit University of Padova-Italy have consulted with the reporter Chiara Di Paola to feature the research.

Rizzoli Orthopaedic Institute researchers present ADIPOA-2 widely

Researchers at the Rizzoli Orthopaedic Institute in Bologna have been busy presenting ADIPOA-2 findings at a variety of national and international conferences. Below please find a list of their dissemination activities to inform and educate others in the research community of our scientific plan and findings.

  1. Oral presentation at “Le Cellule Staminali nella Medicina”. Round table forum: LE CELLULE STAMINALI NELLA MEDICINA TRASLAZIONALE “: Cellule Staminali e Osteoartrite: Il Progetto ADIPOA-2; Gina Lisignoli and Riccardo Meliconi
  2. Oral presentation at the ICRS 2018, 13-14 December 2018 Milan, Italy. Title: ADIPOA Project: Adipose-Derived Stem Cells Biological Effects; Gina Lisignoli.
  3. Oral presentation at the AICC (31st annual conference of Italian Association of Cell Culture), 27-28 November 2018 Bologna, Italy. Title: Mesenchymal stem cells and synoviocytes:development of an in vitro co-culture model; Gina Lisignoli.
  4. Oral presentation at the EORS 2018, 25- 28 September 2018, Galway, Ireland. Title: Adipose mesenchymal stromal cells characteristics are differently modulated by osteoarthritic milieu. Cristina Manferdini, Francesca Paolella, Elena Gabusi, Luca Cattini, Hubert Schrezenmeier, Gina Lisignoli.
  5. Oral presentation at the EORS 2018, 25- 28 September 2018, Galway, Ireland. Title: Switching of the pro-inflammatory profile of synovial osteoarthritic macrophages by adipose mesenchymal stromal cells; Cristina Manferdini, Francesca Paolella, Elena Gabusi, Laura Gambari,  Sandrine Fleury-Cappellesso, Andrea Barbero,  Mary Murphy, Gina Lisignoli.
  6. Oral presentation at OARSI 2018,  26 -29 April 2018, Liverpool, UK. Title: Adipose mesenchymal stromal cells determine the switching of the pro-inflammatory profile of synovial osteoarthritic macrophages; Cristina Manferdini, Francesca Paolella, Elena Gabusi, Laura Gambari,  Giuseppe Filardo, Sandrine Fleury-Cappellesso, Andrea Barbero,  Mary Murphy, Gina Lisignoli.
  7. Poster presentation at the SCR meeting 25-27 May 2017, Chieti, Italy. Title: Switching of a M1 inflammatory macrophages subset by adipose stromal cells contributes to resolution of osteoarthritic synovial tissue inflammation; C Manferdini, F Paolella, E Gabusi, L Gambari, L Cattini, A Piacentini, S Fleury-Cappellesso, A Barbero, M Murphy, G Lisignoli.
  8. Poster presentation at the EULAR 2017 14-17 June 2017 Madrid, Spain. Title: Adipose stromal cells exert specific effects on osteoarthritic synovial macrophages; Manferdini C, Paolella F., Gabusi E., Piacentini A., Gambari L., Cattini L., Fleury-Cappellesso S., Lisignoli G
  9. Oral presentation at the ICRS held 24-27 September 2016, Sorrento, IT. Title: Adipose stromal cells exert specific effects on osteoarthritic synovial macrophages; Manferdini C, Paolella F., Gabusi E., Piacentini A., Gambari L., Cattini L., Fleury-Cappellesso S.,  Lisignoli G.
  10. Poster presentation at TERMIS 27 June-04 July 2016, Uppsala, Sweden Title: Adipose stromal cells effects on osteoarthritic synovial cells are dependent by macrophages; C Manferdini, F Paolella, E Gabusi, L Gambari, L Cattini, S Fleury-Cappellesso, A Barbero, G Lisignoli.
  11. Poster presentation at the OARSI 2016 World Congress, March 31-April 3 Amsterdam, Netherlands. Title: Adipose stromal cells effects on osteoarthritic synoviocytes are dependent by macrophages; Manferdini C,  Gabusi E., Piacentini A.,  Paolella F., Fleury-Cappellesso S., Jorgensen C., Noël D., Barbero A., Lisignoli G.
  12. Poster presentation at the SCR meeting 21– 23 June 2016 Bologna, Italy. Title: Adipose stromal cells effects on osteoarthritic synovial cells are dependent by macrophages; C Manferdini1, F Paolella1, E Gabusi1, L Gambari, L Cattini, S Fleury-Cappellesso, A Barbero4, G Lisignoli